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Article

Partial depletion of CREB-binding protein reduces life expectancy in a mouse model of Huntington disease.

Journal of neuropathology and experimental neurology - 1 Apr 2010

Klevytska Alexandra M, Tebbenkamp Andrew T N, Savonenko Alena V, Borchelt David R

Abstract excerpt

Previous studies have reported that mutant huntingtin (htt) interferes with cyclic AMP response element binding protein binding protein (CBP)-mediated transcription, possibly by inhibiting the acetylation of histones. In Drosophila models that express fragments of mutant htt, histone deacetylase inhibitors reverse deficits in histone acetylation, rescue photoreceptor degeneration, and prolong their survival....

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Source

Identifiers

PMID: 20448484
DOI: 10.1097/NEN.0b013e3181d6c436

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Partial depletion of CREB-binding protein reduces life expectancy in a mouse model of Huntington disease.PMID 20448484Read ↗

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Mutant huntingtin represses CBP, but not p300, by binding and protein degradationSemantic proximity Read ↗

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