Article

Site-specific transgenesis of the <i>D. melanogaster</i> Y-chromosome using CRISPR/Cas9

2018-04-27

Abstract excerpt

Despite the importance of Y-chromosomes in evolution and sex determination, their heterochromatic, repeat-rich nature makes them difficult to sequence and genetically manipulate, and therefore they generally remain poorly understood. For example, the D. melanogaster Y-chromosome, one of the best understood, is widely heterochromatic and composed mainly of highly repetitive sequences, with only a handful of expres...

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Literature Corpus work: c9eac3e6-36ee-58dd-a181-27fdb7fd028f
DOI: 10.1101/310318

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