Article
The C terminus of collagen SQT-3 has complex and essential functions in nematode collagen assembly.
Genetics - 1 Apr 2006
Novelli Jacopo, Page Antony P, Hodgkin Jonathan
Abstract excerpt
The nematode exoskeleton is a multilayered structure secreted by the underlying hypodermal cells and mainly composed of small collagens, which are encoded by a large gene family. In previous work, we reported analysis of the C. elegans dpy-31 locus, encoding a hypodermally expressed zinc-metalloprotease of the BMP-1/TOLLOID family essential for viability and cuticle deposition. We have generated a large set of...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Chromosome Mapping
- Cloning, Molecular
- Collagen
- Helminth Proteins
- Metalloendopeptidases
- Microscopy, Fluorescence
- Models, Genetic
- Molecular Sequence Data
- Mutation, Missense
- Non-Fibrillar Collagens
- Polymers
- Protein Structure, Tertiary
- Transgenes