Combined extracellular matrix cross-linking activity of the peroxidase MLT-7 and the dual oxidase BLI-3 is critical for post-embryonic viability in Caenorhabditis elegans.

doi:10.1074/jbc.M900831200

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Article

Combined extracellular matrix cross-linking activity of the peroxidase MLT-7 and the dual oxidase BLI-3 is critical for post-embryonic viability in Caenorhabditis elegans.

The Journal of biological chemistry - 26 Jun 2009

Thein Melanie C, Winter Alan D, Stepek Gillian, McCormack Gillian, Stapleton Genevieve, Johnstone Iain L, Page Antony P

Abstract excerpt

The nematode cuticle is a protective collagenous extracellular matrix that is modified, cross-linked, and processed by a number of key enzymes. This Ecdysozoan-specific structure is synthesized repeatedly and allows growth and development in a linked degradative and biosynthetic process known as molting. A targeted RNA interference screen using a cuticle collagen marker has been employed to identify components of...

Topics

Amino Acid Sequence
Animals
Animals, Genetically Modified
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Collagen
Cross-Linking Reagents
Embryo, Nonmammalian
Extracellular Matrix

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Gene Expression Regulation, Developmental

Male

Molecular Sequence Data

Mutation

NADPH Oxidases

Peroxidases

Phenotype

RNA Interference

Source

Open in PubMed Open full text

Identifiers

PMID: 19406744
DOI: 10.1074/jbc.M900831200
PMCID: PMC2719394

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