The Caenorhabditis elegans ERp60 Homolog Protein Disulfide Isomerase-3 Has Disulfide Isomerase and Transglutaminase-like Cross-linking Activity and Is Involved in the Maintenance of Body Morphology

Abstract excerpt

A novel protein disulfide isomerase gene, pdi-3, was isolated from the nematode Caenorhabditis elegans. This gene encodes an enzyme related to the ERp60 class of thioredoxin proteins and was found to exhibit unusual enzymatic properties. Recombinant protein displayed both disulfide bond isomerase activity and calcium-dependent transglutaminase-like cross-linking activity. The pdi-3 transcript was developmentally...

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