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Article

Gene interactions in Caenorhabditis elegans define DPY-31 as a candidate procollagen C-proteinase and SQT-3/ROL-4 as its predicted major target.

Genetics - 1 Nov 2004

Novelli Jacopo, Ahmed Shawn, Hodgkin Jonathan

Abstract excerpt

Zinc metalloproteases of the BMP-1/TOLLOID family (also known as astacins) are extracellular enzymes involved in important developmental processes in metazoans. We report the characterization of the Caenorhabditis elegans gene dpy-31, which encodes the first essential astacin metalloprotease identified in this organism. Loss-of-function mutations in dpy-31 result in cuticle defects, abnormal morphology, and...

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Identifiers

PMID: 15579684
DOI: 10.1534/genetics.104.027953
PMCID: PMC1448789

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