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Article

Bias of allele-sharing linkage statistics in the presence of intermarker linkage disequilibrium.

BMC genetics - 30 Dec 2005

Goode Ellen L, Badzioch Michael D, Jarvik Gail P

Abstract excerpt

Current genome-wide linkage-mapping single-nucleotide polymorphism (SNP) panels with densities of 0.3 cM are likely to have increased intermarker linkage disequilibrium (LD) compared to 5-cM microsatellite panels. The resulting difference in haplotype frequencies versus that predicted may affect multipoint linkage analysis with ungenotyped founders; a common haplotype may be assumed to be rare, leading to...

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PMID: 16451697
DOI: 10.1186/1471-2156-6-S1-S82
PMCID: PMC1866698

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NPL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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