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Article

Implication of next-generation sequencing on association studies.

BMC genomics - 17 Jun 2011

Siu Hoicheong, Zhu Yun, Jin Li, Xiong Momiao

Abstract excerpt

BACKGROUND: Next-generation sequencing technologies can effectively detect the entire spectrum of genomic variation and provide a powerful tool for systematic exploration of the universe of common, low frequency and rare variants in the entire genome. However, the current paradigm for genome-wide association studies (GWAS) is to catalogue and genotype common variants (5% < MAF). The methods and study design for...

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Identifiers

PMID: 21682891
DOI: 10.1186/1471-2164-12-322
PMCID: PMC3148210

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MAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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