Article
Equivalence of single- and multilocus markers: power to detect linkage with composite markers derived from biallelic loci.
American journal of human genetics - 1 May 2000
Wilson A F, Sorant A J
Abstract excerpt
The reintroduction of biallelic markers, now in the form of single-nucleotide polymorphisms (SNPs), has again raised concerns about the practicality of the use of markers with low heterozygosity for genomic screening for complex traits, even if thousands of such markers are available. Like the ea...
Topics
- Alleles
- Chromosome Mapping
- Computer Simulation
- Gene Frequency
- Genetic Linkage
- Genetic Markers
- Haplotypes
- Heterozygote
- Humans
- Matched-Pair Analysis
- Models, Genetic
- Nuclear Family
- Polymorphism, Single Nucleotide
- Sensitivity and Specificity
- Software