Genome-wide linkage analysis for alcohol dependence: a comparison between single-nucleotide polymorphism and microsatellite marker assays.

doi:10.1186/1471-2156-6-S1-S8

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Article

Genome-wide linkage analysis for alcohol dependence: a comparison between single-nucleotide polymorphism and microsatellite marker assays.

BMC genetics - 30 Dec 2005

Ma Qianli, Yu Yi, Meng Yan, Farrell John, Farrer Lindsay A, Wilcox Marsha A

Abstract excerpt

Both theoretical and applied studies have proven that the utility of single nucleotide polymorphism (SNP) markers in linkage analysis is more powerful and cost-effective than current microsatellite marker assays. Here we performed a whole-genome scan on 115 White, non-Hispanic families segregating for alcohol dependence, using one 10.3-cM microsatellite marker set and two SNP data sets (0.33-cM, 0.78-cM spacing)....

Topics

Alcoholism
Alleles
Genetic Linkage
Genetic Techniques
Genome-Wide Association Study
Humans
Lod Score
Microsatellite Repeats
Polymorphism, Single Nucleotide

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Identifiers

PMID: 16451694
DOI: 10.1186/1471-2156-6-S1-S8
PMCID: PMC1866701

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