Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Whole-genome scan, in a complex disease, using 11,245 single-nucleotide polymorphisms: comparison with microsatellites.

American journal of human genetics - 1 Jul 2004

John Sally, Shephard Neil, Liu Guoying, Zeggini Eleftheria, Cao Manqiu, Chen Wenwei, Vasavda Nisha, Mills Tracy, Barton Anne, Hinks Anne, Eyre Steve, Jones Keith W, Ollier William, Silman Alan, Gibson Neil, Worthington Jane, Kennedy Giulia C

Abstract excerpt

Despite the theoretical evidence of the utility of single-nucleotide polymorphisms (SNPs) for linkage analysis, no whole-genome scans of a complex disease have yet been published to directly compare SNPs with microsatellites. Here, we describe a whole-genome screen of 157 families with multiple cases of rheumatoid arthritis (RA), performed using 11,245 genomewide SNPs. The results were compared with those from a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis, Rheumatoid
Share to Chromosome Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to Family

Share to Genetic Linkage

Share to Genome, Human

Share to Major Histocompatibility Complex

Share to Microsatellite Repeats

Source

Open in PubMed Open full text

Identifiers

PMID: 15154113
DOI: 10.1086/422195
PMCID: PMC1182008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole-genome scan, in a complex disease, using 11,245 single-nucleotide polymorphisms: comparison with microsatellites.PMID 15154113Read ↗

Whole genome association study of rheumatoid arthritis using 27 039 microsatellites.Semantic proximity Read ↗

Dense genome-wide linkage analysis of rheumatoid arthritis, including covariates.Semantic proximity Read ↗

A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases.Semantic proximity Read ↗

A systematic method for mapping multiple loci: an application to construct a genetic network for rheumatoid arthritis.Semantic proximity Read ↗

Fine-scale structure of the genome and markers used in association mapping.Semantic proximity Read ↗

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.Semantic proximity Read ↗

Recent advances in the genetics of RA susceptibility.Semantic proximity Read ↗

High-density SNP analysis of 642 Caucasian families with rheumatoid arthritis identifies two new linkage regions on 11p12 and 2q33.Semantic proximity Read ↗

Integration of sequence data from a Consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene.Semantic proximity Read ↗

A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set.Semantic proximity Read ↗

Examining the overlap between genome-wide rare variant association signals and linkage peaks in rheumatoid arthritis.Semantic proximity Read ↗

Current understanding of the genetic aetiology of rheumatoid arthritis and likely future developments.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.