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Article

Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice.

PLoS genetics - 1 Jan 2006

Xia Xu-Gang, Zhou Hongxia, Samper Enrique, Melov Simon, Xu Zuoshang

Abstract excerpt

RNA interference (RNAi) has been used increasingly for reverse genetics in invertebrates and mammalian cells, and has the potential to become an alternative to gene knockout technology in mammals. Thus far, only RNA polymerase III (Pol III)-expressed short hairpin RNA (shRNA) has been used to make shRNA-expressing transgenic mice. However, widespread knockdown and induction of phenotypes of gene knockout in...

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Identifiers

PMID: 16450009
DOI: 10.1371/journal.pgen.0020010
PMCID: PMC1358942

Genes

SOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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