Article
Exploring the genetic basis of disease using RNA interference.
Expert review of molecular diagnostics - 1 Sept 2004
Kissler Stephan, Van Parijs Luk
Abstract excerpt
Cancer and autoimmunity are polygenic diseases. In order to better understand the mechanisms of disease development and progression it is essential to uncover which genes are involved. Much has been learned from population studies in human patients by searching for polymorphic genetic loci associated with disease. In addition, animal models of tumor development, as well as models for various autoimmune conditions...
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