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Article

Genetic variation in insulin pathway genes and distal colorectal adenoma risk.

International journal of colorectal disease - 1 Dec 2012

Levine A Joan, Ihenacho Ugonna, Lee Won, Figueiredo Jane C, Vandenberg David J, Edlund Christopher K, Davis Brian D, Stern Mariana C, Haile Robert W

Abstract excerpt

BACKGROUND: Insulin, glucose, and other insulin-related proteins that mediate insulin signaling are associated with colorectal neoplasia risk, but associations with common genetic variation in insulin axis genes are less clear. In this study, we used a comprehensive tag single-nucleotide polymorphisms (SNPs) approach to define genetic variation in six insulin axis genes (IGF1, IGF2, IGFBP1, IGFBP3, IRS1, and...

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Source

Identifiers

PMID: 22645077
DOI: 10.1007/s00384-012-1505-8

Genes

ESR2
IGF2
ESR1
IGF1
IGFBP1
IGFBP3
IRS1
IRS2
PGR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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