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Article

Insulin-like growth factor axis gene polymorphisms modify risk of pancreatic cancer.

Cancer epidemiology - 1 Apr 2012

Dong Xiaoqun, Li Yanan, Tang Hongwei, Chang Ping, Hess Kenneth R, Abbruzzese James L, Li Donghui

Abstract excerpt

OBJECTIVE: Insulin-like growth factor (IGF)-axis genes plays a critical role in cancer development and progression via their impact on the RAS/MAPK/ERK and PI3K/AKT/mTOR signaling pathways. We hypothesized that IGF-axis genetic variants modify individual susceptibility to pancreatic cancer. METHODS: We retrospectively genotyped 41 single-nucleotide polymorphisms of 10 IGF-axis genes (IGF1, IGF2, IGF1R, IGF2R,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21852217
DOI: 10.1016/j.canep.2011.05.013

Genes

IGF1
IGFBP1
IGFBP3
IRS1
IGF2
IGFBP5
IRS2
IRS4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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