Article
Single nucleotide polymorphisms in the IGF-IRS pathway are associated with outcome in mCRC patients enrolled in the FIRE-3 trial.
International journal of cancer - 15 Jul 2017
Schirripa Marta, Zhang Wu, Heinemann Volker, Cao Shu, Okazaki Satoshi, Yang Dongyun, Loupakis Fotios, Berger Martin D, Ning Yan, Miyamoto Yuji, Suenaga Mitsukuni, Gopez Roel F, West Jordan D, Hanna Diana, Barzi Afsaneh, Falcone Alfredo, Stintzing Sebastian, Lenz Heinz-Josef
Abstract excerpt
The Insulin-like growth factor (IGF)/IGF-receptor pathway with its scaffolding proteins Insulin Receptor Substrate (IRS)1 and IRS2 are crucial regulators of metabolism and progression in metastatic colorectal cancer (mCRC). The goal of the study was the identification of predictive and prognostic markers among IRS1, IRS2, IGF1 and IGF-1R SNPs in mCRC patients enrolled in the FIRE-3 trial. Four SNPs of IRS (IRS1...
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