Article
Fibroblast growth factor receptor 1 (Fgfr1) is not essential for lens fiber differentiation in mice.
Molecular vision - 10 Jan 2006
Zhao Haotian, Yang Ying, Partanen Juha, Ciruna Brian G, Rossant Janet, Robinson Michael L
Abstract excerpt
PURPOSE: The developing lens expresses at least three different FGF receptor genes (Fgfr1, Fgfr2, Fgfr3). Furthermore, FGFs have been shown to induce lens epithelial cells to differentiate into fiber cells both in vitro and in vivo. While the loss of Fgfr2 alone does not prevent fiber differentiation and the loss of Fgfr3 alone does not appear to affect lens development, the independent role of Fgfr1 in lens...
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