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Article

Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning.

The EMBO journal - 16 Mar 1998

Celli G, LaRochelle W J, Mackem S, Sharp R, Merlino G

Abstract excerpt

Despite a wealth of experimental data implicating fibroblast growth factor (FGF) signaling in various developmental processes, genetic inactivation of individual genes encoding specific FGFs or their receptors (FGFRs) has generally failed to demonstrate their role in vertebrate organogenesis due to early embryonic lethality or functional redundancy. Here we show that broad mid-gestational expression of a novel...

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Identifiers

PMID: 9501086
DOI: 10.1093/emboj/17.6.1642
PMCID: PMC1170512

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