Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation.

Developmental biology - 15 Jun 2008

Zhao Haotian, Yang Tianyu, Madakashira Bhavani P, Thiels Cornelius A, Bechtle Chad A, Garcia Claudia M, Zhang Huiming, Yu Kai, Ornitz David M, Beebe David C, Robinson Michael L

Abstract excerpt

The vertebrate lens provides an excellent model to study the mechanisms that regulate terminal differentiation. Although fibroblast growth factors (FGFs) are thought to be important for lens cell differentiation, it is unclear which FGF receptors mediate these processes during different stages of lens development. Deletion of three FGF receptors (Fgfr1-3) early in lens development demonstrated that expression of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Enlargement
Share to Cyclin-Dependent Kinase Inhibitor p27

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p57

Share to Eye Abnormalities

Share to Lens, Crystalline

Share to Receptor, Fibroblast Growth Factor, Type 1

Share to Receptor, Fibroblast Growth Factor, Type 2

Share to Receptor, Fibroblast Growth Factor, Type 3

Source

Open in PubMed Open full text

Identifiers

PMID: 18455718
DOI: 10.1016/j.ydbio.2008.03.028
PMCID: PMC2574794

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation.PMID 18455718Read ↗

Requirement for TGFβ receptor signaling during terminal lens fiber differentiationSemantic proximity Read ↗

Fibroblast growth factor receptor 1 (Fgfr1) is not essential for lens fiber differentiation in mice.Semantic proximity Read ↗

A comprehensive spatial-temporal transcriptomic analysis of differentiating nascent mouse lens epithelial and fiber cellsSemantic proximity Read ↗

Pax6 is essential for lens fiber cell differentiation.Semantic proximity Read ↗

Disruption of lens fiber cell differentiation and survival at multiple stages by region-specific expression of truncated FGF receptors.Semantic proximity Read ↗

The tumor suppressor merlin is required for cell cycle exit, terminal differentiation, and cell polarity in the developing murine lens.Semantic proximity Read ↗

Identification and Characterization of FGF2-Dependent mRNA: microRNA Networks During Lens Fiber Cell DifferentiationSemantic proximity Read ↗

Prox1 function is crucial for mouse lens-fibre elongation.Semantic proximity Read ↗

Persistent FoxE3 expression blocks cytoskeletal remodeling and organelle degradation during lens fiber differentiation.Semantic proximity Read ↗

Bmp signaling is required for development of primary lens fiber cells.Semantic proximity Read ↗

Activation of the hedgehog signaling pathway in the developing lens stimulates ectopic FoxE3 expression and disruption in fiber cell differentiation.Semantic proximity Read ↗

Xenopus laevis FGF receptor substrate 3 (XFrs3) is important for eye development and mediates Pax6 expression in lens placode through its Shp2-binding sites.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.