Article
fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation.
Genes & development - 15 Dec 1994
Yamaguchi T P, Harpal K, Henkemeyer M, Rossant J
Abstract excerpt
Experiments in amphibians have implicated fibroblast growth factors (FGFs) in the generation and patterning of mesoderm during embryogenesis. We have mutated the gene for fibroblast growth factor receptor 1 (fgfr-1) in the mouse to genetically dissect the role of FGF signaling during development....
Topics
- Animals
- Base Sequence
- Cloning, Molecular
- Crosses, Genetic
- DNA Primers
- Embryonic and Fetal Development
- Exons
- Female
- Fetal Death
- Fibroblast Growth Factors
- Gastrula
- Genes, Lethal
- Genetic Markers
- Genotype
- Heterozygote
- Kanamycin Kinase
- Male
- Mesoderm