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Article

fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation.

Genes & development - 15 Dec 1994

Yamaguchi T P, Harpal K, Henkemeyer M, Rossant J

Abstract excerpt

Experiments in amphibians have implicated fibroblast growth factors (FGFs) in the generation and patterning of mesoderm during embryogenesis. We have mutated the gene for fibroblast growth factor receptor 1 (fgfr-1) in the mouse to genetically dissect the role of FGF signaling during development. In the absence of fgfr-1 signaling, embryos displayed early growth defects; however, they remained capable of...

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PMID: 8001822
DOI: 10.1101/gad.8.24.3032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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