Article
Analysis of polymorphisms of the interleukin-18 gene in type 1 diabetes and Hardy-Weinberg equilibrium testing.
Diabetes - 1 Feb 2006
Szeszko Jeffrey S, Howson Joanna M M, Cooper Jason D, Walker Neil M, Twells Rebecca C J, Stevens Helen E, Nutland Sarah L, Todd John A
Abstract excerpt
Recently, the interleukin-18 cytokine gene (IL18) was reported to be associated with type 1 diabetes. In the present report, we calculated that the reported genotypes of the two 5' region/promoter single nucleotide polymorphisms (SNPs), -607 (C-->A) (rs1946518) and -137 (G-->C) (rs187238), were not in Hardy-Weinberg equilibrium (HWE). We therefore investigated the association of the -607 and -137 SNPs in a U.K....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.