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Interleukin-18 (rs187238) and glucose transporter 4 (rs5435) polymorphisms in Euro-Brazilians with type 1 diabetes.

Genetics and molecular research : GMR - 21 Sept 2017

Al-Lahham Y, Mendes A K B, Souza E M, Alberton D, Rego F G M, Valdameri G, Picheth G

Abstract excerpt

Type 1 diabetes (T1D) is an autoimmune disease with a strong genetic component that has been associated with several genetic loci. Interleukin 18 (IL-18) is a potent proinflammatory cytokine, which is involved in the innate and adaptive immune responses, and in the pathogenesis of various diseases including T1D. Glucose transporter 4 (GLUT4) is known to be an insulin-responsive glucose transporter and has been...

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PMID: 28973736
DOI: 10.4238/gmr16039755

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