Article
Inhibition of DNA binding of Sox2 by the SUMO conjugation.
Biochemical and biophysical research communications - 29 Dec 2006
Tsuruzoe Shu, Ishihara Ko, Uchimura Yasuhiro, Watanabe Sugiko, Sekita Yoko, Aoto Takahiro, Saitoh Hisato, Yuasa Yasuhito, Niwa Hitoshi, Kawasuji Michio, Baba Hideo, Nakao Mitsuyoshi
Abstract excerpt
Sox2 is a member of the high mobility group (HMG) domain DNA-binding proteins for transcriptional control and chromatin architecture. The HMG domain of Sox2 binds the DNA to facilitate transactivation by the cooperative transcription factors such as Oct3/4. We report that mouse Sox2 is modified by SUMO at lysine 247. Substitution of the target lysine to arginine lost the sumoylation but little affected...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.