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Article

Bioselection of a gain of function mutation that enhances adenovirus 5 release and improves its antitumoral potency.

Cancer research - 1 Nov 2008

Gros Alena, Martínez-Quintanilla Jordi, Puig Cristina, Guedan Sonia, Molleví David G, Alemany Ramon, Cascallo Manel

Abstract excerpt

Genetic bioselection of a mutagenized Ad5wt stock in human tumor xenografts led us to isolate AdT1, a mutant displaying a large-plaque phenotype in vitro and an enhanced systemic antitumor activity in vivo. AdT1 phenotype correlates with an increased progeny release without affecting total viral...

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PMID: 18974137
DOI: 10.1158/0008-5472.CAN-08-1145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18974137-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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