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Article

Directed Evolution of Adenoviruses.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2016

Smith Jason G

Abstract excerpt

The ability to evolve viruses in cell culture in the face of selective pressure is an invaluable method to elucidate the molecular mechanisms of synthetic or natural antivirals, expand tropism, or alter virulence. Recently, mutations to the human adenovirus polymerase that reduce replicative fidelity were described, and we have incorporated one of these mutations into the pol gene of a conditionally replicating...

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Identifiers

PMID: 26611587
DOI: 10.1007/978-1-4939-3271-9_13

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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