Article
Importin-beta family members mediate alpharetrovirus gag nuclear entry via interactions with matrix and nucleocapsid.
Journal of virology - 1 Feb 2006
Butterfield-Gerson Kristin L, Scheifele Lisa Z, Ryan Eileen P, Hopper Anita K, Parent Leslie J
Abstract excerpt
The retroviral Gag polyprotein orchestrates the assembly and release of virus particles from infected cells. We previously reported that nuclear transport of the Rous sarcoma virus (RSV) Gag protein is intrinsic to the virus assembly pathway. To identify cis- and trans-acting factors governing nucleocytoplasmic trafficking, we developed novel vectors to express regions of Gag in Saccharomyces cerevisiae. The...
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