Article
Specific interaction of capsid protein and importin-alpha/beta influences West Nile virus production.
Biochemical and biophysical research communications - 6 Nov 2009
Bhuvanakantham Raghavan, Chong Mun-Keat, Ng Mah-Lee
Abstract excerpt
West Nile virus (WNV) capsid (C) protein has been shown to enter the nucleus of infected cells. However, the mechanism by which C protein enters the nucleus is unknown. In this study, we have unveiled for the first time that nuclear transport of WNV and Dengue virus C protein is mediated by their direct association with importin-alpha. This interplay is mediated by the consensus sequences of bipartite nuclear...
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