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Article

A novel nuclear export activity in HIV-1 matrix protein required for viral replication.

Nature - 9 Dec 1999

Dupont S, Sharova N, DéHoratius C, Virbasius C M, Zhu X, Bukrinskaya A G, Stevenson M, Green M R

Abstract excerpt

An important aspect of the pathophysiology of human immunodeficiency virus type-1 (HIV-1) infection is the ability of the virus to replicate in non-dividing cells. HIV-1 matrix (MA), the amino-terminal domain of the Pr55 gag polyprotein (Pr55), bears a nuclear localization signal that promotes localization of the viral preintegration complex to the nucleus of non-dividing cells following virus entry. However,...

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Source

Identifiers

PMID: 10604476
DOI: 10.1038/45272

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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