Article
The respiratory syncytial virus matrix protein possesses a Crm1-mediated nuclear export mechanism.
Journal of virology - 1 Jun 2009
Ghildyal Reena, Ho Adeline, Dias Manisha, Soegiyono Lydia, Bardin Phillip G, Tran Kim C, Teng Michael N, Jans David A
Abstract excerpt
The respiratory syncytial virus (RSV) matrix (M) protein is localized in the nucleus of infected cells early in infection but is mostly cytoplasmic late in infection. We have previously shown that M localizes in the nucleus through the action of the importin beta1 nuclear import receptor. Here, we establish for the first time that M's ability to shuttle to the cytoplasm is due to the action of the nuclear export...
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