Inter-strain variation in susceptibility to hyperoxic injury of murine airways.

Abstract excerpt

The contribution of genetic background in susceptibility to hyperoxic lung injury is not clear. We utilized inbred mice to: 1) characterize inter-strain variation in hyperoxia-induced effects on lavageable indicators of airway epithelial injury; 2) test the hypothesis that hyperoxia-induced change in airway permeability is under Mendelian control. Male mice (5-7 wk, 20-25 g) from six inbred strains were exposed...

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