Article
Specific functions for the fission yeast Sirtuins Hst2 and Hst4 in gene regulation and retrotransposon silencing.
The EMBO journal - 16 May 2007
Durand-Dubief Mickaël, Sinha Indranil, Fagerström-Billai Fredrik, Bonilla Carolina, Wright Anthony, Grunstein Michael, Ekwall Karl
Abstract excerpt
Expression profiling, ChiP-CHIP and phenotypic analysis were used to investigate the functional relationships of class III NAD(+)-dependent HDACs (Sirtuins) in fission yeast. We detected significant histone acetylation increases in Sirtuin mutants at their specific genomic binding targets and were thus able to identify an in vivo substrate preference for each Sirtuin. At heterochromatic loci, we demonstrate that...
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