Article
Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription.
Molecular cell - 1 Jun 2000
Galarneau L, Nourani A, Boudreault A A, Zhang Y, Héliot L, Allard S, Savard J, Lane W S, Stillman D J, Côté J
Abstract excerpt
NuA4 is an essential histone H4/H2A acetyltransferase complex that interacts with activators and stimulates transcription in vitro. We have identified three novel NuA4 subunits: Act3/Arp4, an actin-related protein implicated in epigenetic control of transcription, Act1, and Epl1, a protein homologous to Drosophila Enhancer of Polycomb. Act3/Arp4 binds nucleosomes in vitro and is required for NuA4 integrity in...
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