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Article

Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells.

American journal of physiology. Cell physiology - 1 Jun 2005

Yu Alan S L, McCarthy Karin M, Francis Stacy A, McCormack Joanne M, Lai Jean, Rogers Rick A, Lynch Robert D, Schneeberger Eveline E

Abstract excerpt

The function of occludin (Occ) in the tight junction is undefined. To gain insight into its role in epithelial cell biology, occludin levels in Madin-Darby canine kidney II cells were suppressed by stably expressing short interfering RNA. Suppression of occludin was associated with a decrease in claudins-1 and -7 and an increase in claudins-3 and -4. Claudin-2 levels were unaffected. The tight junction "fence"...

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Identifiers

PMID: 15689410
DOI: 10.1152/ajpcell.00581.2004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells.PMID 15689410Read ↗

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