Article
Connexin45 directly binds to ZO-1 and localizes to the tight junction region in epithelial MDCK cells.
FEBS letters - 7 Sept 2001
Kausalya P J, Reichert M, Hunziker W
Abstract excerpt
Zonula occludens protein 1 (ZO-1) is a cytosolic tight junction protein that tethers transmembrane proteins such as occludin, claudin and junctional adhesion molecule to the actin cytoskeleton. The interaction between ZO-1 and claudin or junctional adhesion molecule occurs via the amino-terminal PSD95/Dlg/ZO-1 (PDZ) domains in ZO-1. A yeast two-hybrid screen to search for proteins that interact with the PDZ...
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