Article
Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions.
The Journal of cell biology - 1 Dec 1994
Furuse M, Itoh M, Hirase T, Nagafuchi A, Yonemura S, Tsukita S, Tsukita S
Abstract excerpt
Occludin is an integral membrane protein localizing at tight junctions (TJ) with four transmembrane domains and a long COOH-terminal cytoplasmic domain (domain E) consisting of 255 amino acids. Immunofluorescence and laser scan microscopy revealed that chick full-length occludin introduced into h...
Topics
- Animals
- Cell Compartmentation
- Cell Polarity
- Cells, Cultured
- Chickens
- Cytoplasm
- Fluorescent Antibody Technique
- Humans
- Intercellular Junctions
- Membrane Proteins
- Models, Molecular
- Mutation
- Occludin
- Phosphoproteins
- Protein Binding