Article
NAT1 and NAT2 genetic polymorphisms and environmental exposure as risk factors for oesophageal squamous cell carcinoma: a case-control study.
BMC cancer - 18 Mar 2015
Matejcic Marco, Vogelsang Matjaz, Wang Yabing, Iqbal Parker M, Parker Iqbal M
Abstract excerpt
BACKGROUND: Tobacco smoking and red meat consumption are some of the known risk factors associated with the development of oesophageal cancer. N-acetytransferases (NAT1 and NAT2) play a key role in metabolism of carcinogenic arylamines present in tobacco smoke and overcooked red meat. We hypothes...
Topics
- Aged
- Alcohol Drinking
- Arylamine N-Acetyltransferase
- Carcinoma, Squamous Cell
- Case-Control Studies
- Environmental Exposure
- Esophageal Neoplasms
- Esophageal Squamous Cell Carcinoma
- Female
- Humans
- Isoenzymes
- Male
- Meat
- Middle Aged
- Polymorphism, Single Nucleotide
- Risk Factors
- Smoking
- South Africa