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Article

Phospholemman inhibition of the cardiac Na+/Ca2+ exchanger. Role of phosphorylation.

The Journal of biological chemistry - 24 Mar 2006

Zhang Xue-Qian, Ahlers Belinda A, Tucker Amy L, Song Jianliang, Wang JuFang, Moorman J Randall, Mounsey J Paul, Carl Lois L, Rothblum Lawrence I, Cheung Joseph Y

Abstract excerpt

We have demonstrated previously that phospholemman (PLM), a 15-kDa integral sarcolemmal phosphoprotein, inhibits the cardiac Na+/Ca2+ exchanger (NCX1). In addition, protein kinase A phosphorylates serine 68, whereas protein kinase C phosphorylates both serine 63 and serine 68 of PLM. Using human embryonic kidney 293 cells that are devoid of both endogenous PLM and NCX1, we first demonstrated that the exogenous...

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Identifiers

PMID: 16434394
DOI: 10.1074/jbc.M512092200
PMCID: PMC1405234

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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