Article
Residues 248-252 and 300-304 of the cardiac Na+/Ca2+ exchanger are involved in its regulation by phospholemman.
American journal of physiology. Cell physiology - 1 Oct 2011
Zhang Xue-Qian, Wang JuFang, Song Jianliang, Ji Angi M, Chan Tung O, Cheung Joseph Y
Abstract excerpt
Using split cardiac Na(+)/Ca(2+) exchangers (NCX1), we previously demonstrated that phospholemman (PLM) regulates NCX1 by interacting with the proximal linker domain (residues 218-358) of the intracellular loop of NCX1. With the use of overlapping loop deletion mutants, interaction sites are localized to two regions spanning residues 238-270 and residues 300-328 of NCX1. In this study, we used alanine (Ala)...
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