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Article

Cardiac hypertrophy in mice expressing unphosphorylatable phospholemman.

Cardiovascular research - 1 Oct 2014

Boguslavskyi Andrii, Pavlovic Davor, Aughton Karen, Clark James E, Howie Jacqueline, Fuller William, Shattock Michael J

Abstract excerpt

AIMS: Elevation of intracellular Na in the failing myocardium contributes to contractile dysfunction, the negative force-frequency relationship, and arrhythmias. Although phospholemman (PLM) is recognized to form the link between signalling pathways and Na/K pump activity, the possibility that defects in its regulation contribute to elevation of intracellular Na has not been investigated. Our aim was to test the...

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Source

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Identifiers

PMID: 25103111
DOI: 10.1093/cvr/cvu182
PMCID: PMC4174889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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