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Article

Inhibition of phospholamban phosphorylation by O-GlcNAcylation: implications for diabetic cardiomyopathy.

Glycobiology - 1 Oct 2010

Yokoe Shunichi, Asahi Michio, Takeda Toshihiro, Otsu Kinya, Taniguchi Naoyuki, Miyoshi Eiji, Suzuki Keiichiro

Abstract excerpt

Cardiac-type sarco(endo)plasmic reticulum Ca(2)-ATPase (SERCA2a) plays a major role in cardiac muscle contractility. Phospholamban (PLN) regulates the function of SERCA2a via its Ser(16)-phosphorylation. Since it has been proposed that the Ser/Thr residues on cytoplasmic and nuclear proteins are modified by O-linked N-acetylglucosamine (O-GlcNAc), we examined the effect of O-GlcNAcylation on PLN function in rat...

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Identifiers

PMID: 20484118
DOI: 10.1093/glycob/cwq071

Genes

PLN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inhibition of phospholamban phosphorylation by O-GlcNAcylation: implications for diabetic cardiomyopathy.PMID 20484118Read ↗

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