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Article

Characterization of the phospholemman knockout mouse heart: depressed left ventricular function with increased Na-K-ATPase activity.

American journal of physiology. Heart and circulatory physiology - 1 Feb 2008

Bell James R, Kennington Erika, Fuller William, Dighe Kushal, Donoghue Pamela, Clark James E, Jia Li-Guo, Tucker Amy L, Moorman J Randall, Marber Michael S, Eaton Philip, Dunn Michael J, Shattock Michael J

Abstract excerpt

Phospholemman (PLM, FXYD1), abundantly expressed in the heart, is the primary cardiac sarcolemmal substrate for PKA and PKC. Evidence supports the hypothesis that PLM is part of the cardiac Na-K pump complex and provides the link between kinase activity and pump modulation. PLM has also been proposed to modulate Na/Ca exchanger activity and may be involved in cell volume regulation. This study characterized the...

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Source

Identifiers

PMID: 18065526
DOI: 10.1152/ajpheart.01332.2007

Genes

SDS
FXYD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterization of the phospholemman knockout mouse heart: depressed left ventricular function with increased Na-K-ATPase activity.PMID 18065526Read ↗

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