Article
Identification of tumour rejection antigens recognized by T lymphocytes.
Cancer surveys - 1 Jan 1992
Boon T, De Plaen E, Lurquin C, Van den Eynde B, van der Bruggen P, Traversari C, Amar-Costesec A, Van Pel A
Abstract excerpt
On the basis of the results reviewed here, there are two major mechanisms whereby tumour rejection antigens may arise. The first mechanism is mutational. Point mutations occurring in a large variety of genes may produce new antigenic peptides, either by providing them with the ability to bind to MHC class I molecules or by providing them with a new epitope (Fig. 2). The second mechanism is the activation of a...
Topics
- Animals
- Antigens, Neoplasm
- Base Sequence
- Graft Rejection
- Humans
- Immunologic Surveillance
- Molecular Sequence Data
- Mutation
- Neoplasms, Experimental
- T-Lymphocytes
- Transfection