Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

T cell recognition of transforming proteins encoded by mutated ras proto-oncogenes.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 1991

Peace D J, Chen W, Nelson H, Cheever M A

Abstract excerpt

Activated ras proto-oncogenes contribute to the pathogenesis of many animal and human malignancies. ras proto-oncogenes are generally activated by point mutations within codons 12 or 61, which result in the expression of ras protein (p21) bearing characteristic single amino acid substitutions at the corresponding residues. The purpose of the current study was to determine whether the presence of single...

Topics

Amino Acid Sequence
Animals
Antigen-Presenting Cells
Cell Transformation, Neoplastic
Female
Histocompatibility Antigens Class II
Immunization
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Peptide Fragments

Proto-Oncogene Proteins p21(ras)

T-Lymphocytes

Source

Identifiers

PMID: 2005390

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2005390-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

T cell recognition of transforming proteins encoded by mutated ras proto-oncogenes.PMID 2005390Read ↗

Induction of T cells specific for the mutated segment of oncogenic P21ras protein by immunization in vivo with the oncogenic protein.Semantic proximity Read ↗

Human T lymphocytes recognize a peptide of single point-mutated, oncogenic ras proteins.Semantic proximity Read ↗

Induction in transgenic mice of HLA-A2.1-restricted cytotoxic T cells specific for a peptide sequence from a mutated p21ras protein.Semantic proximity Read ↗

Subunit peptide cancer vaccines targeting activating mutations of the p21 ras proto-oncogene.Semantic proximity Read ↗

Cytotoxic T-cell response and in vivo protection against tumor cells harboring activated ras proto-oncogenes.Semantic proximity Read ↗

Mutations in residue 61 of H-Ras p21 protein influence MHC class II presentation.Semantic proximity Read ↗

Recognition of simian virus 40 T antigen by cytotoxic T lymphocytes.Semantic proximity Read ↗

Induction and characterization of cytotoxic T-lymphocytes recognizing a mutated p21ras peptide presented by HLA-A*0201.Semantic proximity Read ↗

Naturally occurring T-cell response against mutated p21 ras oncoprotein in pancreatic cancer.Semantic proximity Read ↗

Differential binding to frequent HLA-A alleles of p21 RAS derived peptides bearing oncogenic substitutions at position 12 or 13.Semantic proximity Read ↗

Epitopic characterization of the human wild-type and mutant ras proteins using membrane-bound peptides.Semantic proximity Read ↗

Cytotoxic CD4+ and CD8+ T lymphocytes, generated by mutant p21-ras (12Val) peptide vaccination of a patient, recognize 12Val-dependent nested epitopes present within the vaccine peptide and kill autologous tumour cells carrying this mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.