Article
Successful induction of immune responses against mutant ras in melanoma patients using intradermal injection of peptides and GM-CSF as adjuvant.
Experimental dermatology - 1 Jun 2001
Hunger R E, Brand C U, Streit M, Eriksen J A, Gjertsen M K, Saeterdal I, Braathen L R, Gaudernack G
Abstract excerpt
The rapidly increasing incidence and mortality rate of malignant melanoma, together with the lack of efficient treatment of the late stages, makes it a serious threat to public health. Innovative new treatments are needed. The proteins of the ras-family of proto-oncogenes, functioning as relay switches for signalling pathways between cell surface and nucleus, are involved in cell proliferation, differentiation,...
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