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Article

A SNP in the flt-1 promoter integrates the VEGF system into the p53 transcriptional network.

Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 2006

Menendez Daniel, Krysiak Oliver, Inga Alberto, Krysiak Bianca, Resnick Michael A, Schönfelder Gilbert

Abstract excerpt

The VEGF system is essential for angiogenesis. VEGF overexpression frequently correlates with increased microvascularity and metastasis and decreased spontaneous apoptosis. Although a precise mechanism has not been established, studies suggest that VEGF expression is negatively regulated by p53, a master regulator and tumor suppressor. There are no reports of additional components of the VEGF signal transduction...

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Source

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Identifiers

PMID: 16432214
DOI: 10.1073/pnas.0508103103
PMCID: PMC1360546

Genes

FLT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A SNP in the flt-1 promoter integrates the VEGF system into the p53 transcriptional network.PMID 16432214Read ↗

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