Article
The role of vascular endothelial growth factor SNPs as predictive and prognostic markers for major solid tumors.
Molecular cancer therapeutics - 1 Sept 2009
Jain Lokesh, Vargo Craig A, Danesi Romano, Sissung Tristan M, Price Douglas K, Venzon David, Venitz Jürgen, Figg William D
Abstract excerpt
Angiogenesis is crucial for development and metastasis of tumors, and vascular endothelial growth factor (VEGF) is a key mediator of this process. The importance of VEGF in tumorigenesis and tumor progression makes it an attractive target for the development of anticancer therapies. Inhibition of angiogenesis has shown promising clinical efficacy; however, not all patients treated with antiangiogenic agents...
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