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TNF gene polymorphisms are associated with reduced survival in severe Chagas' disease cardiomyopathy patients.

Microbes and infection - 1 Mar 2006

Drigo Sandra A, Cunha-Neto Edecio, Ianni Bárbara, Cardoso Maria Regina A, Braga Patrícia E, Faé Kellen C, Nunes Vera Lopes, Buck Paula, Mady Charles, Kalil Jorge, Goldberg Anna Carla

Abstract excerpt

Chronic Chagas' disease cardiomyopathy (CCC) is the most important clinical outcome of infection by the parasite Trypanosoma cruzi, affecting 18 million individuals in Latin America. One-third of CCC patients develop heart failure due to end-stage dilated cardiomyopathy, and their survival is reduced by 50% compared to patients with other cardiomyopathies. Genetic susceptibility may play a role in the...

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Source

Identifiers

PMID: 16427798
DOI: 10.1016/j.micinf.2005.08.009

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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