Article
Association of -308G/A polymorphism in the tumor necrosis factor-alpha gene promoter with susceptibility to development of hantavirus cardiopulmonary syndrome in the Ribeirão Preto region, Brazil.
Archives of virology - 1 Jun 2010
Borges Alessandra Abel, Donadi Eduardo Antônio, Campos Gelse Mazzoni, Moreli Marcos Lázaro, de Sousa Ricardo Luiz Moro, Saggioro Fabiano Pinto, de Figueiredo Glauciane Garcia, Badra Soraya Jabur, Deghaide Neifi Hassan Saloum, Figueiredo Luiz Tadeu Moraes
Abstract excerpt
Activation of the immune response in hantavirus cardiopulmonary syndrome (HCPS) leads to a high TNF production, probably contributing to the disease. The polymorphic TNF2 allele (TNF -308G/A) has been associated with increased cytokine production. We investigated the association of the TNF2 allele with the outcome of hantavirus infection in Brazilian patients. A total of 122 hantavirus-exposed individuals (26...
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