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Article

Nucleotide channel of RNA-dependent RNA polymerase used for intermolecular uridylylation of protein primer.

Journal of molecular biology - 24 Mar 2006

Tellez Andres B, Crowder Scott, Spagnolo Jeannie F, Thompson Aaron A, Peersen Olve B, Brutlag Douglas L, Kirkegaard Karla

Abstract excerpt

Poliovirus VPg is a 22 amino acid residue peptide that serves as the protein primer for replication of the viral RNA genome. VPg is known to bind directly to the viral RNA-dependent RNA polymerase, 3D, for covalent uridylylation, yielding mono and di-uridylylated products, VPg-pU and VPg-pUpU, which are subsequently elongated. To model the docking of the VPg substrate to a putative VPg-binding site on the 3D...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16427083
DOI: 10.1016/j.jmb.2005.12.044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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