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Article

A "slide-back" mechanism for the initiation of protein-primed RNA synthesis by the RNA polymerase of poliovirus.

The Journal of biological chemistry - 7 Nov 2003

Paul Aniko V, Yin Jiang, Mugavero JoAnn, Rieder Elizabeth, Liu Ying, Wimmer Eckard

Abstract excerpt

Poliovirus RNA replication is initiated when a molecule of UMP is covalently linked to the hydroxyl group of a tyrosine in the terminal protein VPg. This reaction can be reproduced in vitro with an assay that utilizes two purified viral proteins, RNA polymerase 3Dpol and viral protein 3CDpro, synthetic VPg, UTP, and Mg2+. The template for the reaction is either poliovirus RNA or transcripts of a small RNA...

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PMID: 12937178
DOI: 10.1074/jbc.M307441200

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